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New Research: Glyphosate-based herbicide exposure during pregnancy and lactation malprograms the male reproductive morphofunction in F1 offspring

7/23/2019

Jakeline Liara Teleken (a1), Ellen Carolina Zawoski Gomes (a1), Carine Marmentini (a1), Milara Bruna Moi (a1) ...

- DOI: https://doi.org/10.1017/S2040174419000382
- Published online by Cambridge University Press: 16 July 2019

AbstractOne of the most consumed pesticides in the world is glyphosate, the active ingredient in the herbicide ROUNDUP®. Studies demonstrate that glyphosate can act as an endocrine disruptor and that exposure to this substance at critical periods in the developmental period may program the fetus to induce reproductive damage in adulthood. Our hypothesis is that maternal exposure to glyphosate during pregnancy and lactation in mice will affect the development of male reproductive organs, impairing male fertility during adult life. Female mice consumed 0.5% glyphosate-ROUNDUP® in their drinking water [glyphosate-based herbicide (GBH) group] or filtered water [control (CTRL) group] from the fourth day of pregnancy until the end of the lactation period. Male F1 offspring were designated, according to their mother’s treatment, as CTRL-F1 and GBH-F1. Female mice that drank glyphosate displayed reduced body weight (BW) gain during gestation, but no alterations in litter size. Although GBH male F1 offspring did not exhibit modifications in BW, they demonstrated delayed testicular descent. Furthermore, at PND150, GBH-F1 mice presented a lower number of spermatozoa in the cauda epididymis and reduced epithelial height of the seminiferous epithelium. Notably, intratesticular testosterone concentrations were enhanced in GBH-F1 mice; we show that it is an effect associated with increased plasma and pituitary concentrations of luteinizing hormone. Therefore, data indicate that maternal exposure to glyphosate-ROUNDUP® during pregnancy and lactation may lead to decreased spermatogenesis and disruptions in hypothalamus–pituitary–testicular axis regulation in F1 offspring. Read More click here

Water hazards for dogs: These 7 things could harm Spot. Flesh-eating bacteria isn't one.

7/13/2019

If you have a dog and take to the beach or water etc in any area (NOT just Florida), please read this so you know the dangers. I wrote a blog post about dogs in our area and the Vet who is helping bring awareness - click here to read that story from 2018

Tyler Treadway, Treasure Coast Newspapers
Published 9:49 a.m. ET July 12, 2019

Costa, a 4-year-old golden retriever, looks and acts like an old dog.

Last September, Costa nearly died from eating a clump of toxic blue-green algae behind the house she shares with her owners, Adam and Ashley Guzi, on the St. Lucie River near Stuart.

"She's lucky to be alive," Ashley Guzi said, "but she hasn't been the same. She wears herself out quickly; her face has turned white, like an old dog's. Before the algae, she was still in her puppy phase; but now she acts like a senior dog."

Costa survived because Guzi took her quickly to a veterinarian who recognized the symptoms of an encounter with toxic algae.

Water hazards for pets

Blue-green algae isn't the only potential toxic threat to your pets in Florida waters. Other algae and bacteria known to make people sick, or even be fatal, can harm pets, too.

Read More CLICK HERE

10 tips for understanding food labels

7/13/2019

Understanding food labels
Supermarket shelves are full of foods and drinks, many of them making claims that sound healthy. Hannah Elliott explains how to use back-of-pack food labels to make healthy choices.

Food labelling can help us make an informed decision when shopping, but understanding the labels can feel difficult. While colour-coded front-of-pack labelling is a simple way to decode a nutrition label, not all manufacturers use this system.

Back-of-pack information can still give you the same information, and can also provide more detail about the product’s nutritional content and the ingredients inside.

Here are 10 easy tips to help you read back-of-packet labelling:

1. Read the ingredients list
Most pre-packaged foods have an ingredients list on the back of the packet. Everything that goes into your food will be listed in weight order from biggest to the smallest. So if the first few ingredients contain saturated fat - like cream, butter, fatty meat or cheese - or sugars, whether white or brown sugar, syrups or concentrated fruit juice, it’s worth bearing in mind that these make up the largest proportion of the food.

Ingredients that appear further down the list will be added in small quantities, but that doesn’t always make their impact insignificant. Vitamins and minerals added to some breakfast cereals, for example, can make a positive impact on our diets, while even small amounts of salt can make a significant contribution to our maximum of 6g a day.

READ MORE: CLICK HERE

Thanks to Heart Matters Magazine

Life-extending lung cancer treatment recommended for use on the NHS

7/13/2019

05 July 2019

Dacomitinib has been recommended as a first-line treatment option for people with a type of non-small-cell lung cancer (NSCLC), in new NICE guidance.

This once-a-day pill will be available on the NHS for adults with locally advanced or metastatic NSCLC, who have tested positive for the epidermal growth factor receptor (EGFR) mutation.

This is a change from the committee’s initial decision which found dacomitinib to not be a cost-effective use of NHS resources.

Clinical trial results showed that people who took dacomitinib had longer overall survival rates than those who took gefitinib (34.1 months compared with 26.8 months), a drug already recommended by NICE. Dacomitinib also increased the length of time before the disease worsened (14.7 months for dacomitinib compared with 9.2 months for gefitinib). It was however noted that dacomitinib had a higher incidence of side effects than gefitinib, so a lower dose may be needed.

Meindert Boysen, director of the Centre for Health Technology Evaluation at NICE, said: “Our committee acknowledged that dacomitinib had the potential to extend life for people with this type of lung cancer more than existing treatments currently available on the NHS.

"Responsible pricing by the company has allowed our committee to reconsider their initial decision. This has led to the positive recommendation announced today, allowing patients to benefit from this innovative treatment on the NHS.”

According to company estimates around 1,477 people will be eligible for this treatment annually.

Read more CLICK HERE
THANK YOU TO NHS

Sugary drinks linked to cancer

7/13/2019

Thursday 11 July 2019

"Drinking a third of a fizzy drink a day 'increases risk of breast cancer by 22% – and fruit juice is just as dangerous'," reports the Sun.

The headline is based on a large ongoing study that assessed sugary and artificially sweetened drink intake in more than 100,000 adults in France.

All drinks with high levels of sugar were considered, including 100% fruit juices and sugary fizzy drinks.

The researchers followed the participants up over time to see whether those who drank more of these drinks were more likely to develop cancer.

Read More CLICK HERE
Thank you to NHS

13 soft drinks ranked best to worst

7/13/2019

We’ve ranked 13 popular drinks from best to worst based on their nutritional value – in particular sugar and fat. Read on to quench your thirst the heart-healthy way.

1. Water
Hydrating, inexpensive and sugar-free: water is the best choice for drinking over the day. If you want to give it some flavour without adding sugar, try adding ice cubes and fresh mint or strips of cucumber.

To read more click here

Thanks to Heart Matters Magazine

New Research: Glyphosate-based herbicide exposure during pregnancy and lactation malprograms the male reproductive morphofunction in F1 offspring

Water hazards for dogs: These 7 things could harm Spot. Flesh-eating bacteria isn't one.

10 tips for understanding food labels

Life-extending lung cancer treatment recommended for use on the NHS

Sugary drinks linked to cancer

13 soft drinks ranked best to worst

Categories

Archives

New Research: Glyphosate-based herbicide exposure during pregnancy and lactation malprograms the male reproductive morphofunction in F1 offspring

Water hazards for dogs: These 7 things could harm Spot. Flesh-eating bacteria isn't one.

​10 tips for understanding food labels

Life-extending lung cancer treatment recommended for use on the NHS

Sugary drinks linked to cancer

​13 soft drinks ranked best to worst

Categories

Archives

10 tips for understanding food labels

13 soft drinks ranked best to worst